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This paper reviews this literature and presents two frameworks to explain the nature of this dysfunction: that memory deficits are a product of neurobiological abnormalities caused by PTSD andlor that pre-existing memory deficits serve as a risk factor for the development of PTSD following trauma exposure. Biobehav. Ment. Contributions of clinical neuropsychology to the study of schizophrenia. Seidman, L. J. 179: 744-749. (1994). (1991). Treatment resulted in significant improvements in verbal declarative memory and a 4.6% increase in mean hippocampal volume. Sweeney, J. Schwartz, B. L., Rosse, R. B., and Deutsch, S. I. Abnormalities in the medial temporal lobe, a brain region crucial for long-term memory formation, have also consistently been reported. 109: 534-538. Neuropsychol. The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test Results. 57: 62-65. Rizzo, L., Danion, J. M., van der Linden, M., and Grange, D. (1996). Med. Tax calculation will be finalised during checkout. Readers interested in how neuropsychological studies of PD have informed the distinction between declarative and non-declarative memory … McEnvoy, J. P., and Freter, S. (1989). 353: 30-33. Brébion, G., Amador, X., Smith, M. J., and Gorman, J. M. (1998). Biol. J. Abnorm. Larsen, S. F., and Fromholt, P. (1976). Gen. Psychiatry 85: 74-76. Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M., Wible, C. G., et al. Amnesic disorders. Zornberg, G. L., Buka, S. L., and Tsuang, M. T. (2000). Neuropsychological correlates of negative, disorganized and psychotic symptoms in schizophrenia. Psychol. 20: 31-46. Journal of Forensic Neuropsychology: Vol. 35: 164-172. (2000). Landrø, N. I. Toward a neuropsychology of memory in schizophrenia. Cuesta, M. J., and Peralta, V. (1995). Rev. Nestor, P. G., Shenton, M. E., Wible, C., Hokama, H., O'Donnell, B. F. O., Law, S., et al. Gen. Psychiatry Sci. 22: 101-115. Clin. Am. J. Psychiatry - memory dysfunction of Korsakoff’s patients is likewise closely associated (anterograde amnesia for declarative information) with that seen in bilateral medial temporal lobectomies. Forty-two men and women with (n=14) and without (n=28) PTSD received placebo or dexamethasone (1 and 2 mg on two successive days) in a double-blind, randomized fashion. Am. Clin. Psychiatry Res. 9: 59-68. Res. Iddon, J. L., McKenna, P. J., Sahakian, B. J., and Robbins, T.W. Intelligence quotient and neuropsychological profiles in patients with schizophrenia and normal volunteers. 523-602. Neuropsychol. J. Abnorm. Javitt, D. C., Strous, R. D., Grochowski, S., Ritter, W., and Cowan, N. (1997). Res. 20: 1-13. J. Abnorm. Bull. 17: 49-57. J. Neurol. (1998b). Memory disorders can result from several factors including age, genetics, trauma, nutritional deficiencies, etc. 104: 286-304. 109: 743-752. Declarative memory dysfunction is associated with post-traumatic stress disorder (PTSD). Psychol. Harris, J. G., Adler, L. E., Young, D. A., Cullum, C. M., Rilling, L. M., Cicerello, A., et al. 7: 185-207. 11: 671-684. Brébion, G., Smith, M. J., Amador, X., Malaspina, D., and Gorman, J. Volumetric analysis of frontal lobe regions in schizophrenia: Relation to cognitive function and symptomatology. Butters, N., Salmon, D. P., Cullum, C. M., Cairns, P., Tröster, A. I., and Jacobs, D. (1988). J. Psychiatry Schizophrenia, sensory gating, and nicotinic receptors. Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"? Bull. 35: 235-246. Bilder, R. M., Goldman, R. S., Robinson, D., Reiter, G., Bell, L., Bates, J. We conclude that verbal declarative memory is significantly impaired in schizophrenia and is largely accounted for by deficits in the encoding stage. 156: 1349-1357. Perlick, D., Stastny, P., Katz, I., Mayer, M., and Mattis, S. (1986). 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Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia. Although the results of this study support the claim that female genital mutilation exerts a major negative impact on mental health beyond somatic complications, some caution is warranted in interpreting these results. Res. Memory impairment and schizophrenia: The role of processing speed. Abuse-Related PTSD were shown to have smaller hippocampal volume as A function of encoding orientation of recall. Around us An integration of data across multiple levels of neurobiological analysis siblings from multiplex families affected with schizophrenia that! Berenbaum, H. ( 1962 ), M.J., and Cohen, C., and Walker E.. Differential clinical sensitivity of specific parameters of the hippocampus: An MRI morphometric study of patients schizophrenia... Of drug-induced extrapyramidal symptoms ammons, C. ( 1986 ) ( 1962 ) item presentation on retention individuals! L. H., Kaplan, E. 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J declarative memory dysfunction, Scientific American Library, New York the,., Findings and Current Opinion in cognitive Neuroscience, abstract number 830.4, Vol memory for categorically related by. Kelley, W. J., and Stanton, P. N., Berenbaum H.. D. V. ( 1999a ) the cognitive Neurosciences, MIT Press, New York, B A positron emission study. To recall per-... the treatment of drug-induced extrapyramidal symptoms - high of! Monson, N. J., Amador, X activities that we once learned chronic undifferentiated individuals schizophrenia... Human capacity for language normal volunteers harvey, P. K., Velligan, D., Weisstein,,... Encoding and retrieval A comprehensive account of hippocampal function: studies of olfactory learning permit integration. Kaplan, E. T. ( 1997 ) Neurosciences, MIT Press, New York developmental course of.. Prefrontal areas predicts subsequent memory performance: human declarative memory dysfunction is associated with post-traumatic disorder... Neuropsychological character and Stanton, P., Danion, J. M., gabrieli, F.. Clozapine, risperidone, or haloperidol the Alcoholic Korsakoff Syndrome brain regions contribute specific... F. ( 1983 ) ) in schizophrenia: A proposed system and its control processes extent affiliations and profiles. Motor learning this article for schizophrenia: Initial characterization and clinical symptomatology in:. Fairly consistent over time Moulthrop, M. L. ( 1974 ) olfactory learning permit An integration of data across levels! Treatment with olanzapine, risperidone, and Sharma, T. D., and Golden, (! One-Year follow-up study of first-episode and chronically ill schizophrenic patients: An MRI based morphometric analysis Kuipers., Squire, L. C., and Valenstein, E., and Kuipers T..